| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5224859 | Tetrahedron | 2008 | 7 Pages |
Abstract
The cyclisation of a series of ethyl 3â²-phenyl-4â²,6â²-dimethoxyindol-7â²-yl-2-(hydroxyimino)acetates was investigated using 1H NMR spectroscopy to determine the mechanism of formation of the corresponding ethyl 6,8-dimethoxypyrazolo[4,5,1-hi]indole-5-carboxylates. The electronic requirements of the reaction were determined and used, along with the effect of removing the ester functionality, to determine that the reaction proceeds through a concerted intramolecular substitution.
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Organic Chemistry
![Mechanisms of cyclisation of indolo oxime ethers. Part 2: Formation of ethyl 6,8-dimethoxypyrazolo[4,5,1-hi]indole-5-carboxylates](/preview/png/5224859.png "First Page Preview: Mechanisms of cyclisation of indolo oxime ethers. Part 2: Formation of ethyl 6,8-dimethoxypyrazolo[4,5,1-hi]indole-5-carboxylates")
Authors
Kylie A. Clayton, David StC. Black, Jason B. Harper,