Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5224915 | Tetrahedron | 2010 | 11 Pages |
The structure elucidation of a novel natural product pavettamine (1), the causal agent of the plant toxicosis gousiekte, is reported. The structure was defined by analysis of NMR and MS data and the relative configuration followed from the 13C NMR data of the acetonide derivative. The absolute stereochemistry was established by total synthesis from (2S)-malic acid using chiral sulfoxide methodology as (2S,4R,8R,10S)-1,11-diamino-6-aza-undecane-2,4,8,10-tetraol.
Graphical abstractThe structure and relative configuration of a novel natural product, pavettamine, was defined by analysis of NMR and MS data. The absolute stereochemistry was established by total synthesis from (2S)-malic acid using chiral sulfoxide methodology.Download full-size image