Efficient radical domino approach to β-aminoalcohols from arylamines and alcohols triggered by Ti(III)/t-BuOOH

We report that an aqueous Ti(III)/t-BuOOH system promotes the efficient domino radical reaction of arylamines with alcohol cosolvents leading to β-aminoalcohols in good yields, in less than ten minutes at room temperature. The free-radical mechanism according to which the amine reacts with two molecules of the alcohol is discussed.

Graphical abstractDownload full-size image