Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5224921 | Tetrahedron | 2010 | 6 Pages |
Abstract
A wide range of 2-arylbenzo[b]furans are synthesized through domino intermolecular C(aryl)-C(alkynyl) bond formation followed by intramolecular C(alkynyl)-O bond forming cyclization via copper(II)-catalyzed coupling of o-iodophenols and aryl terminal acetylenes. This method requires neither expensive palladium catalyst nor oxophilic phosphine ligands, can tolerate different functional groups. The methodology is successfully utilized in formal synthesis of β-amyloid aggregation inhibitor 5-chloro-3-[4-(3-diethylaminopropoxy)benzoyl]-2-(4-methoxyphenyl) benzofuran.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
E.A. Jaseer, D.J.C. Prasad, Govindasamy Sekar,