| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5224974 | Tetrahedron | 2008 | 10 Pages |
Abstract
The rapid synthesis of the western biaryl portion of TMC-95 is disclosed via the use of a Diels–Alder reaction with o-nitrostyrene derivative and 1-silyloxy diene with excellent regiochemical control. Subsequent sequential substitutions of a p-iodo-phenol derivative followed by an o-bromo-nitrobenzene intermediate are employed to incorporate the western carbon framework of TMC-95.
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