Article ID Journal Published Year Pages File Type
5224997 Tetrahedron 2007 8 Pages PDF
Abstract

A simple and efficient one-pot three-component synthesis of the biologically important spirooxindoles scaffold was carried out by the reaction of isatin, activated methylene reagent, and 1,3-dicarbonyl compounds in aqueous medium. This method is of great value because of its environmentally benign character, high yield processing, and easy handling.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry