Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5224997 | Tetrahedron | 2007 | 8 Pages |
Abstract
A simple and efficient one-pot three-component synthesis of the biologically important spirooxindoles scaffold was carried out by the reaction of isatin, activated methylene reagent, and 1,3-dicarbonyl compounds in aqueous medium. This method is of great value because of its environmentally benign character, high yield processing, and easy handling.
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