Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5225038 | Tetrahedron | 2007 | 9 Pages |
Abstract
The palladium(II)-promoted reaction of a variety of olefins and bromamine-T provided N-tosyl-2-substituted aziridines under mild conditions. Olefins bearing chiral appendages gave only a poor to modest diastereoselectivity. Appropriate deuterated olefins were selected to study the stereochemistry of the reaction. A Pd(IV) intermediate is proposed as the aziridinating species.
Graphical abstractA simple method is described for the palladium(II) mediated aziridination of a broad range of olefins using bromamine-T as the nitrogen source.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Alexandra M.M. Antunes, Vasco D.B. Bonifácio, Susana C.C. Nascimento, Ana M. Lobo, Paula S. Branco, Sundaresan Prabhakar,