Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5225076 | Tetrahedron | 2008 | 8 Pages |
Abstract
An efficient synthesis of new dioxygenated isoquinolines is reported. The novelty of this approach derives from its use of tricyclic-nitril (3) as a building block in a synthetic sequence of seven steps for the preparation of the tetracyclic isoquinoline (14) and its derivatives. The isoquinoline 16 was 10-fold more active against leukemia L1210 than the corresponding tetrahydroisoquinoline 14.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Manel Romero, Daniel-Henry Caignard, Pierre Renard, M. Dolors Pujol,