| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5225077 | Tetrahedron | 2008 | 6 Pages |
Abstract
Two novel cyclopropyl diketones, hamavellone A (1) and B (2), and two new 14-membered nonaketide macrolactones, hamigeromycin A (3) and B (4), together with six known compounds, 89-250904-F1 (radicicol analogue A, 5), pseurotin A (6), emodin (7), Ï-hydroxyemodin (8), and emodin bianthrones (9 and 10) were isolated from the soil fungus Hamigera avellanea BCC 17816. The structures of the new compounds were defined by analysis of NMR and MS data. The absolute stereochemistry of 3 was addressed by chemical correlation to 5. Hamavellone B (2) exhibited antimalarial activity with an IC50 of 5.2 μg/mL, whereas it also showed comparable cytotoxicity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Masahiko Isaka, Panida Chinthanom, Sukitaya Veeranondha, Sumalee Supothina, J. Jennifer Luangsa-ard,