Total synthesis of (±)-methyl-kinamycin C

The first total synthesis of the proposed structure for methyl-kinamycin C (methyl-KC), derived from KC, was achieved via two key steps: Diels–Alder reaction of benzindenone and Danishefsky-type diene, and the stereoselective construction of highly oxygenated D ring. Good accordance of the spectral data of synthesized title compound with those of natural KC and its derivative was observed.

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