Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5225218 | Tetrahedron | 2007 | 10 Pages |
Abstract
Stereoselective synthesis of an immunomodulator (+)-conagenin was achieved. Both amine and carboxylic acid moieties were prepared from commercially available optically active methyl 3-hydroxy-2-methylpropanoate using dirhodium(II)-catalyzed C-H amination and chelation-controlled reductions as key steps. In addition, demethyl analogs of conagenin were synthesized using similar procedures.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takayuki Yakura, Yuya Yoshimoto, Chisaki Ishida, Shunsuke Mabuchi,