Article ID Journal Published Year Pages File Type
5225218 Tetrahedron 2007 10 Pages PDF
Abstract

Stereoselective synthesis of an immunomodulator (+)-conagenin was achieved. Both amine and carboxylic acid moieties were prepared from commercially available optically active methyl 3-hydroxy-2-methylpropanoate using dirhodium(II)-catalyzed C-H amination and chelation-controlled reductions as key steps. In addition, demethyl analogs of conagenin were synthesized using similar procedures.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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