Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5225244 | Tetrahedron | 2009 | 7 Pages |
Abstract
A simple highly versatile and efficient synthesis of 2,4,5-trisubstituted imidazoles is achieved by three-component cyclocondensation of 1,2-dicarbonyl compound, aldehyde and ammonium acetate using l-proline as a catalyst in methanol at moderate temperature. To explore the utility of this method 1,2,4,5-tetrasubstituted imidazoles were also synthesized. The key advantages of this process are high yields, cost effectiveness of catalyst, easy work-up and purification of products by non-chromatographic methods.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Subhasis Samai, Ganesh Chandra Nandi, Pallavi Singh, M.S. Singh,