The chemistry of α,β-ditosyloxyketones: new and convenient route for the synthesis of 1,4,5-trisubstituted pyrazoles from α,β-chalcone ditosylates

The reaction of α,β-chalcone ditosylates with various reagents such as phenylhydrazine hydrochloride, semicarbazide hydrochloride and thiosemicarbazide in suitable conditions leads to 1,2-aryl shift, thereby providing a novel route for the synthesis of 1,4,5-trisubstituted pyrazoles.

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