Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5225358 | Tetrahedron | 2007 | 30 Pages |
Abstract
Aplyronine A (2), a potent antitumor macrolide was isolated from the sea hare Aplysia kurodai together with the congeners aplyronines B (3) and C (4). The absolute stereostructure of aplyronine A (2) was determined by the instrumental analysis (mainly NMR and MS) and the enantioselective synthesis of the fragments obtained from chemical degradation of aplyronine A (2). The structures of aplyronines B (3) and C (4) were also elucidated. Cytotoxicity and antitumor activity of aplyronine A (2) were evaluated.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Makoto Ojika, Hideo Kigoshi, Yoshifumi Yoshida, Takeshi Ishigaki, Masanori Nisiwaki, Itaru Tsukada, Masayuki Arakawa, Hisao Ekimoto, Kiyoyuki Yamada,