| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5225365 | Tetrahedron | 2007 | 10 Pages |
Abstract
Stereoselective syntheses of malyngamide X (1) and its 7â²(S)-epimer are described. A Lewis acid (Et2AlCl) mediated anti-aldol reaction was employed to generate the stereocenters C-7 and C-8. The route is convergent and provides a convenient access to the synthesis of structural variants of malyngamide X. Stereochemistry at C-7â² in the molecules of natural and synthetic 1, and 7â²(S)-epi 1 was confirmed by NMR chiral solvation experiments.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Suchada Suntornchashwej, Khanit Suwanborirux, Minoru Isobe,