N-Arylmethyl-7-azabicyclo[2.2.1]heptane derivatives: synthesis and reaction mechanisms

In this manuscript we have reported two new methods for the synthesis of epibatidine analogues bearing the N-arylalkyl and the N-aryl-7-azabicyclo[2.2.1]heptane skeleton. Furthermore, DFT studies have been carried out on the reaction mechanisms to account for the results.