Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5225438 | Tetrahedron | 2009 | 9 Pages |
Abstract
Novel nucleoside analogues based on bicyclo[2.2.1]heptene/heptane were prepared by linear synthesis starting from commercially available 1,2,3,4-tetrachloro-5,5-dimethoxycyclopentadiene 1. The crucial step of the synthesis was insertion of the amino group to the position 7 of the substituted bicyclo[2.2.1]heptene with anti-configuration by a Ritter reaction (H2SO4, AcOH, CH3CN). All nucleobases were constructed at this amino function. The prepared family of the target nucleosides was tested for cytostatic and antiviral activity.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Michal Å ála, Hubert HÅebabecký, Martin DraÄÃnský, Milena MasojÃdková, Armando M. De Palma, Johan Neyts, AntonÃn Holý,