Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5225445 | Tetrahedron | 2009 | 7 Pages |
Abstract
An organocatalytic multicomponent reaction involving 3,4-dihydro-(2H)-pyran, aromatic aldehydes, and urea/thiourea as substrates and l-proline/TFA as catalyst afforded hexahydropyrano pyrimidinones (thiones) in good yields. The method is simple, economical, and ecofriendly to generate hexahydropyrano pyrimidinones as precursors for many biologically active molecules and fused oxazines (PA-824), the lead molecules for tuberculosis chemotherapy.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jyoti Pandey, Namrata Anand, Rama P. Tripathi,