Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5225550 | Tetrahedron | 2007 | 11 Pages |
Abstract
The preparation of functionalized 3,4-pyridynes of type 1 as highly reactive intermediates has been achieved by the controlled elimination of readily generated 2-magnesiated diaryl sulfonates of type 2 obtained by a low temperature I/Mg- or Br/Mg-exchange starting from the corresponding halides of type 3. After trapping with furan, moderate to good yields of the desired functionalized cycloadducts of type 4 are obtained. The addition of a magnesium arylthiolate or magnesium phenylselenide to 3,4-pyridyne followed by quenching with an electrophile is also described.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wenwei Lin, Ling Chen, Paul Knochel,