Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5225580 | Tetrahedron | 2009 | 5 Pages |
Abstract
CuI-catalyzed coupling of 2-bromobenzylamines and α-amino acids and subsequent condensative cyclization (directly or mediated with DPPA) provides 1,4-benzodiazepin-3-ones in moderate yields. Using l-proline and l-valine as the starting materials enantiopure products are obtained although partial racemization occurs for other amino acids.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hexiang Wang, Yongwen Jiang, Kun Gao, Dawei Ma,