Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5225608 | Tetrahedron | 2008 | 6 Pages |
Abstract
Aryl imines formed from aldehydes and amines undergo smoothly in situ nucleophilic addition with trimethylsilyl cyanide (TMSCN) in the presence of catalytic amount of hydrated rhodium(III) iodide to afford the corresponding α-aminonitriles in excellent yield. The low catalytic loading (2 mol %), mild experimental conditions, and short reaction time (mostly within 13 min) represent the key features of this novel catalytic system.
Graphical abstractDownload full-size imageWe have described a very simple, convenient, and practical method for the synthesis of α-aminonitriles through three-component coupling reaction of aldehydes, amines, and TMSCN using rhodium(III) iodide hydrate as catalyst.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Anjoy Majhi, Sung Soo Kim, Santosh T. Kadam,