Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5225681 | Tetrahedron | 2007 | 8 Pages |
Abstract
Various N-substituted benz[g]isoquinoline-3,5,10(2H)-triones 7 were prepared starting from vitamin K3 (menadione) 9. The key steps involve substitution of a benzylic bromide by a primary amine and intramolecular condensation across the ester moiety of a (3-bromomethyl-naphth-2-yl)acetate 8 followed by oxidation with cerium(IV) ammonium nitrate (CAN) and spontaneous dehydrogenation, resulting in the title compounds 7. A selection of the synthesised new compounds was tested in vitro against Mycobacterium tuberculosis.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jan Jacobs, Sven Claessens, Bart Kesteleyn, Kris Huygen, Norbert De Kimpe,