Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5225749 | Tetrahedron | 2008 | 8 Pages |
Abstract
N-Protecting groups of α-substituted cyclic amines strongly affected the regioselectivity in electrochemical methoxylation of these compounds. Namely, N-acyl derivatives were transformed into αâ²-methoxylated compounds, while N-cyano derivatives changed into α-methoxylated derivatives. Furthermore, Lewis acid catalyzed nucleophilic substitution of the α-methoxylated compounds protected with cyano group afforded α,α-disubstituted cyclic amines.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Samuel S. Libendi, Yosuke Demizu, Yoshihiro Matsumura, Osamu Onomura,