A new class of chiral pyrrolidine for asymmetric Michael addition reactions. New mechanism via simple 4+2 type attack of the enamine on the trans-nitrostyrene

Article ID	Journal	Published Year	Pages	File Type
5225799	Tetrahedron	2007	8 Pages	PDF

Abstract

A new chiral organocatalyst is described in this paper. A new mechanism for the overall Michael condensation of ketones with nitroolefins using our catalyst is suggested based on molecular modelling studies.

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Keywords

DFT Michael addition Transition state Proline Pyrrolidines Organocatalysis

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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A new class of chiral pyrrolidine for asymmetric Michael addition reactions. New mechanism via simple 4+2 type attack of the enamine on the trans-nitrostyrene

Authors

David Diez, M. Jose Gil, Rosalina F. Moro, Isidro S. Marcos, P. GarcÃa, P. Basabe, Narciso M. Garrido, Howard B. Broughton, J.G. Urones,