Enantioselective synthesis of condensed and transannular ring skeletons containing pyrrolidine moiety

A new approach toward condensed and transannular ring structures containing pyrrolidine unit has been developed, based on diastereoselective nucleophilic addition of lithium enolate of α-diazoacetoacetate to chiral N-sulfinyl imine and ring-closing metathesis.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide