| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5225897 | Tetrahedron | 2008 | 8 Pages |
Abstract
An efficient total synthesis of the S1P1 agonist, KRP-203, is described. The key step involves the conjugate addition of diethyl acetamidomalonate to a styrene compound to give the core structure of KRP-203. Multigram quantities of the targeted KRP-203, sufficient for several biological studies, were obtained in six steps with an overall yield of 58%.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Masao Chino, Masatoshi Kiuchi, Kunitomo Adachi,