| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5226036 | Tetrahedron | 2009 | 6 Pages |
Abstract
Stereoselective syntheses of several 3-azabicyclo[3.2.0]heptane nucleoside analogues have been efficiently completed starting from a homochiral a,b-unsaturated-g-lactam. The target compounds were prepared by condensation of a common bicyclic acetate intermediate with pyrimidine and purine bases under modified Vorbrüggen conditions. The anti-HIV activity of the newly synthesized azanucleosides has been evaluated.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ramon Flores, Ramon Alibés, Marta Figueredo, Josep Font,