Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5226164 | Tetrahedron | 2008 | 11 Pages |
Abstract
The synthesis, characterization, fluorescence, and singlet oxygen quantum yields of tetraphenylporphyrin and tetraphenylchlorin coupled to RGD type peptide are reported. C-terminus protected RGD derivatives were synthesized in liquid phase at the gram scale via an efficient convergent process. C-terminus unprotected RGD derivatives were synthesized on solid support. The UV-vis, fluorescence, and singlet emission spectra showed that the photophysical properties of the photosensitizers were retained in all compounds and some of them are very promising for potential PDT applications.
Graphical abstractDownload full-size image
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Michel Boisbrun, Régis Vanderesse, Philippe Engrand, Alexis Olié, Sébastien Hupont, Jean-Bernard Regnouf-de-Vains, Céline Frochot,