Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5226199 | Tetrahedron | 2009 | 5 Pages |
Abstract
Readily available N1,N3-diacyl-3,4-dihydropyrimidin-2(1H)-ones efficiently acylate ammonia, primary and secondary amines to furnish primary, secondary and tertiary amides in good to excellent yields. The wide applicability of the procedure is demonstrated by running the reactions in a neutral medium, easy isolation of products, recycling of the innocuous by-product and chemoselectivity of the transformation.
Graphical abstractThe title dihydropyrimidinone reagents perform acylations of ammonia as well as primary and secondary amines in neutral medium to furnish primary, secondary and tertiary amides in a synthetically useful manner. Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kamaljit Singh, Kawaljit Singh,