Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5226394 | Tetrahedron | 2009 | 9 Pages |
Abstract
The development of a ring-opening metathesis/ring-closing metathesis/cross-metathesis (ROM–RCM–CM) cascade strategy to the synthesis of a diverse collection of bi- and tricyclic sultams is reported. In this study, functionalized sultam scaffolds derived from intramolecular Diels–Alder (IMDA) reactions undergo metathesis cascades to yield a collection of tricyclic sultams. Additional appendage-based diversity was achieved by utilizing a variety of CM partners.
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