Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5226409 | Tetrahedron | 2009 | 7 Pages |
Abstract
Two N-benzyl imines are designed to allow for carbon-carbon bond formations at the aminated benzylic positions. Direct benzylic arylation reactions of N-benzylxanthone imine with aryl chlorides proceed under palladium catalysis in the presence of cesium hydroxide, yielding the corresponding benzhydrylamine derivatives. Alkylation reactions of N-benzyldi-1-naphthyl ketone imine with alkyl halides in the presence of potassium tert-butoxide afford the corresponding 1-phenylalkylamines in high yields. Conjugate addition of N-benzyldi-1-naphthyl ketone imine is also described.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takashi Niwa, Takafumi Suehiro, Hideki Yorimitsu, Koichiro Oshima,