Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5226418 | Tetrahedron | 2006 | 13 Pages |
Abstract
A simple and efficient method has been developed for the synthesis of 2-aminothiazoles and N-allylthioureas from commercially available materials in one pot by using a supported reagents system, KSCN/SiO2-RNH3OAc/Al2O3, in which α-halo ketone reacts first KSCN/SiO2 and the product, α-thiocyanatoketone, reacts with RNH3OAc/Al2O3 to give the final product, 2-aminothiazoles, in good yield and allyl bromide reacts with KSCN/SiO2 and the product, allyl isothiocyanate, reacts with RNH3OAc/Al2O3 to give N-allylthiourea.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tadashi Aoyama, Sumiko Murata, Izumi Arai, Natsumi Araki, Toshio Takido, Yoshitada Suzuki, Mitsuo Kodomari,