Synthesis of thiol-modified peptide nucleic acids designed for post-assembly conjugation reactions

Article ID	Journal	Published Year	Pages	File Type
5226423	Tetrahedron	2006	11 Pages	PDF

Keywords

DIC MBHA para-methoxybenzyl TFMSA N-methylmorpholine t-butyloxycarbonyl diisopropylcarbodiimide NMM Triisopropylsilane 9-Fluorenylmethyloxycarbonyl PMB BOC FMOC HOBt EDC Cbz TIS DTT TFA 1-Hydroxybenzotriazole hydrate N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride Trifluoroacetic acid Trifluoromethanesulfonic acid Peptide nucleic acid benzyloxycarbonyl triethylamine Minor diisopropylethylamine dithiothreitol Solid-phase synthesis Major DIPEA HATU Conjugation TEA

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Synthesis of thiol-modified peptide nucleic acids designed for post-assembly conjugation reactions

Authors

Martijn C. de Koning, Lene Petersen, Jimmy J. Weterings, Mark Overhand, Gijsbert A. van der Marel, Dmitri V. Filippov,