| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5226426 | Tetrahedron | 2006 | 8 Pages |
Abstract
Enzymatic acetylations of N-substituted cis- and trans-3,4-dihydroxypiperidine and hydrolysis of their diacetylated derivatives have been studied. High enantioselectivities are obtained with Pseudomonas cepacia lipase and Candida antarctica lipase B for the hydrolysis of the trans-derivative, while the cis-derivatives are not adequate substrates in the same biocatalytic conditions. The enantiopreference of these processes can be rationalized by means of a molecular modelling study.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Laura F. Solares, Iván Lavandera, Vicente Gotor-Fernández, Rosario Brieva, Vicente Gotor,