Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5226475 | Tetrahedron | 2006 | 6 Pages |
Abstract
An efficient enantioselective synthesis of (â)-chloramphenicol (1) and (+)-thiamphenicol (2) is described. These antibiotics have been synthesized from commercially available 4-nitrobenzaldehyde and 4-(methylthio)benzaldehyde, respectively, using tethered aminohydroxylation and Sharpless asymmetric epoxidation as the chirality inducing steps.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shyla George, Srinivasarao V. Narina, Arumugam Sudalai,