Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5226502 | Tetrahedron | 2008 | 11 Pages |
Abstract
The key, versatile precursors N2-(N,N-dimethylaminomethylene)-1â²-O-(4-methoxybenzyl)-3-[2-(4-nitrophenyl)ethyl]biopterin (29a) and its ciliapterin analog (29b) were prepared, respectively, from d-xylose (in 14 steps) and l-xylose (in 11 steps). Treatment of 29a and 29b with 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-d-glucopyranosyl bromide in the presence of silver triflate and tetramethylurea, followed by removal of the protecting groups, led to the first selective syntheses of limipterin (3) and tepidopterin (5), respectively.
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Authors
Tadashi Hanaya, Hiroki Baba, Hiroki Toyota, Hiroshi Yamamoto,