| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5226568 | Tetrahedron | 2009 | 9 Pages |
Abstract
A de novo synthesis of pentoses is described starting from (Z)-2-buten-1,4-diol (1). The key step is the enzyme catalysed enantioselective HCN-addition to O-protected 4-hydroxybut-2-enal using the hydroxynitrile lyase from Hevea brasiliensis, followed by an asymmetric dihydroxylation. For the cyanohydrin reaction the influence of the configuration of the double bond and of the protecting group was investigated. The dihydroxylation step was found to be influenced by the protecting group on position 4.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Manuela Avi, Richard Gaisberger, Sabine Feichtenhofer, Herfried Griengl,