Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5226584 | Tetrahedron | 2009 | 5 Pages |
Abstract
Several new steroid derivatives have been synthesised by the reaction of steroid-amino acid conjugates with N,Nâ²-dicyclohexyl-carbodiimide. Selectivity of the reaction was found to depend greatly on the properties of the amino acid moiety. While the reaction of the glycine derivative led to the corresponding 5(4H)-oxazolone, an unusual imide formation together with an N-acylurea side product was observed in the case of conjugates of l-alanine, l-phenylalanine and l-methionine. The structures of the new products, steroidal imide and N-acylurea derivatives, were determined by various spectroscopic methods.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Eszter Takács, Zoltán Berente, Viktor Háda, Sándor Mahó, László Kollár, Rita Skoda-Földes,