| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5226612 | Tetrahedron | 2006 | 12 Pages |
Abstract
A C,D-seco-paclitaxel derivative 26 was prepared from taxine and tested for biological activity. Chemical reactivity of the seco-compounds proved to be substantially modified, with respects to taxoids. The corresponding C,D-seco-taxoid does not show tubulin stabilizing activity or cytotoxicity. Explanation of these observations based on molecular modeling is provided.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zorana Ferjancic, Radomir Matovic, Zivorad Cekovic, Yi Jiang, James P. Snyder, Vladimir Trajkovic, Radomir N. Saicic,