Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5226688 | Tetrahedron | 2008 | 8 Pages |
Abstract
Total syntheses of the title natural products, pseudopyronines A (1) and B (2), have been achieved using methyl β-oxo carboxylic ester starting materials. The natural products and a small set of structurally related compounds were evaluated for growth inhibitory activity against a range of pathogenic microorganisms and were found to exhibit good potency (IC50â¥0.46 μg/mL) and selectivity towards Leishmania donovani. Several of the compounds inhibited recombinant fatty acid biosynthesis enzymes from both Plasmodium falciparum and Mycobacterium tuberculosis, validating these targets in the search for new anti-infective agents.
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Chemistry
Organic Chemistry
Authors
Anna C. Giddens, Lone Nielsen, Helena I. Boshoff, Deniz Tasdemir, Remo Perozzo, Marcel Kaiser, Feng Wang, James C. Sacchettini, Brent R. Copp,