Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5226691 | Tetrahedron | 2008 | 7 Pages |
Abstract
An efficient and direct protocol for the preparation of amidoalkyl naphthols employing a multi-component and one-pot condensation reaction of 2-naphthol, aromatic aldehydes, and acetonitrile or acetamide in the presence of silica supported perchloric acid under solvent, solvent-free, and microwave irradiation conditions is described. The present protocol with HClO4-SiO2 catalyst is superior to the recently reported catalytic methods. It is noteworthy that 1-amidomethyl-2-naphthols can be converted into important 'drug like' 1-aminomethyl-2-naphthol derivatives by amide hydrolysis.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hamid Reza Shaterian, Hossein Yarahmadi, Majid Ghashang,