| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5226706 | Tetrahedron | 2008 | 12 Pages |
Abstract
A total of 16 alkaloids, exemplified by mersinine A and its congeners, and constituting a new subclass of the monoterpenoid indoles, were isolated exclusively and for the first time from Kopsia singapurensis. The structures of these alkaloids were established by spectroscopic methods and in some instances confirmed by X-ray diffraction analysis. A possible biogenetic route from an aspidofractinine precursor is proposed. Compounds 1, 2, 3, 9, and 10 were found to reverse multidrug-resistance in drug-resistant KB cells.
Graphical abstractDownload full-size image A total of 16 alkaloids characterized by a novel pentacyclic skeleton were isolated from Kopsia singapurensis.
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Physical Sciences and Engineering
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Authors
G. Subramaniam, Yeun-Mun Choo, Osamu Hiraku, Kanki Komiyama, Toh-Seok Kam,