Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5226843 | Tetrahedron | 2008 | 6 Pages |
Abstract
NaClO2/NaI in the presence of HCl is a mild, cheap, and non-toxic reagent for the iodination of phenols, including estradiol and naphthol, aromatic amines, and heterocyclic substrates, e.g., indoles, 8-hydroxyquinoline, imidazole, in fair to excellent yields by a very simple isolation protocol. The scope of the procedure is exemplified by the first iodination of 5-nitroindole to 3-iodo-5-nitroindole in 75% yield.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Liliana Lista, Alessandro Pezzella, Alessandra Napolitano, Marco d'Ischia,