| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5226863 | Tetrahedron | 2009 | 10 Pages |
Abstract
Synthesis of the proposed structure of tyroscherin, a growth inhibitor of IGF-1-dependent cancer cells, was succeeded by one-pot Julia coupling. However, spectral data of the synthetic compound were not identical with those of natural tyroscherin. The stereochemistry of tyroscherin is revised to be 2S,3R,8R,10R by syntheses of stereoisomers. Synthetic tyroscherin showed more potent activity than its stereoisomers against IGF-1-dependent cancer cells.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ken Ishigami, Ryo Katsuta, Chié Shibata, Yoichi Hayakawa, Hidenori Watanabe, Takeshi Kitahara,