| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5226969 | Tetrahedron | 2007 | 6 Pages |
Abstract
Ligulasagitins A-E (1-5), five new eremophilane-derived metabolites possibly formed via a Diels-Alder reaction in the biosynthetic process, were isolated from Ligularia sagitta Maxim. Among them 1 and 2 possess a novel C19 skeleton, 4 and 5 are two novel dimeric eremophilane type derivatives. Their structures were determined by extensive spectroscopic analysis and the structure of 2 was also confirmed by a single-crystal X-ray diffraction analysis. Furthermore, 4 and 5 showed weak cytotoxic activity against HL-60 (human promyelocytic leukemia) cells.
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Authors
Ping-Lin Li, Chun-Ming Wang, Zhan-Xin Zhang, Zhong-Jian Jia,