Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5226999 | Tetrahedron | 2009 | 9 Pages |
Abstract
A copper-catalyzed synthesis of β-haloalkenyl sulfides or selenides was carried out by addition of dichalcogenides and tetrabutylammonium halides to internal alkynes. The present reaction anti- and regio-selectively afforded the corresponding alkenyl chalocogenides, and took advantage of both organochalcogenide-groups on dichalcogenide. Furthermore, the reaction under oxygen atmosphere could employ thiols. The use of the procedure could easily synthesize (Z)-tamoxifen from diphenyl acetylene in three steps.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nobukazu Taniguchi,