Article ID Journal Published Year Pages File Type
5227073 Tetrahedron 2007 8 Pages PDF
Abstract

A concise route to the anti-tumour natural product (−)-varitriol, together with its novel isomer (−)-3′-epi-varitriol, is described using a Horner-Wadsworth-Emmons (HWE)/conjugate addition/Ramberg-Bäcklund sequence as the cornerstone. The flexibility of the synthetic route has been demonstrated by the preparation of novel varitriol analogues.

Graphical abstract

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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