| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5227074 | Tetrahedron | 2007 | 7 Pages |
Abstract
A convergent stereoselective synthesis of the bacterial DNA primase inhibitor Sch 642305 and its non-natural epimer at C-4 is described. A key aspect was the construction of a trans-2,3-disubstituted cyclohexanone system by means of a stereoselective Michael addition/α-alkylation sequence. The macrolactone ring of either stereoisomer was created using the Mitsunobu and Yamaguchi procedures, respectively.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jorge GarcÃa-Fortanet, Miguel Carda, J. Alberto Marco,