Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5227137 | Tetrahedron | 2009 | 5 Pages |
Abstract
A Cu(II)/I2-mediated C-H bond activation is described. A variety of 2-phenylpyridine derivatives are oxidatively dimerized at the ortho-position of the phenyl ring in which a net loss of two hydrogen atoms results in the formation of a biaryl compound via a double C-H activation/C-C bond-forming process. Moderate functional group tolerance was observed on both the aryl and the pyridyl rings. A single electron transfer (SET) or electrophilic metalation process for iodination followed by Ullmann coupling of the intermediate iodinated product is proposed as the operating mechanism for the dimerization process.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiao Chen, Graham Dobereiner, Xue-Shi Hao, Ramesh Giri, Nathan Maugel, Jin-Quan Yu,