| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5227151 | Tetrahedron | 2009 | 9 Pages |
Abstract
Two distinct systems for the rhodium-catalyzed enantioselective desymmetrization of meso-cyclic anhydrides have been developed. Each system has been optimized and are compatible with the use of in situ prepared organozinc reagents. Rhodium/PHOX species efficiently catalyze the addition of alkyl nucleophiles to glutaric anhydrides, while a rhodium/phosphoramidite system is effective in the enantioselective arylation of succinic and glutaric anhydrides.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jeffrey B. Johnson, Matthew J. Cook, Tomislav Rovis,